Edward Grant began his early art education at Wilmington Academy of Art alongside painter and philanthropist Henryette Stadelman Whiteside (1891–1973). Perhaps through Whiteside’s support, Grant studied art with N. C. Wyeth (1882–1945) and his contemporary, Andrew Wyeth (1917–2009). During the Depression, Grant modeled for and studied with illustrator Frank Schoonover (1877–1972) while also working on local mural commissions. He later became the artistic director of Hercules, Inc. After retiring to Neavitt, Maryland, Grant became involved with the artist community centered at The Academy in Easton.